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Population Advice on Salt Restriction:

The Social Issues

Author(s)

BP reduction (mmHg)

Na reduction (mmol/d)

# trials

Randomized only?

Law et al

10.0/5.0

100

23

NO

Cutler et al

1.7/0.97

76

6

Yes

Swales

1.48/0.94

100

9

Yes

Midgley et al

1.0/0.1

100

28

Yes

Cutler et al

1.9/1.1

76

12

Yes

Graudal et al

1.2/0.26

160

56

Yes

Law, MR, Frost, CD, Wald, NJ. "By how much does dietary salt reduction lower blood pressure? III. Analysis of data from trials of salt reduction." British Medical Journal. 1991; 302:819-824.

Cutler, JA, Follmann, D, Elliott, P, Suh, I. "An overview of randomized trials of sodium reduction and blood pressure." Hypertension. 1991; 17(Suppl I): I-27-33.

Swales, JD. "Dietary sodium restriction in hypertension," in Hypertension Pathophysiology, Diagnosis and Management. Ed. JH Laragh and BM Brenner. Raven Press, New York, 1995. P. 283-298.

Midgley, JP, Matthew, AG, Greenwood, CMT, Logan, AG. "Effect of reduced dietary sodium on blood pressure: A meta-analysis of randomized controlled trials. Journal of the American Medical Association. 1996; 275:1590-1597.

Cutler, JA, Follmann, D, Allender, PS. "Randomized trials of sodium reduction: an overview." American Journal of Clinical Nutrition. 1997; 65(suppl):643s-651s.

Graudal, NA, Galloe, AM, Garred, P. "Effects of sodium restriction on blood pressure, renin, aldosterone, catecholamines, cholesterols and triglyceride." Journal of the American Medical Association. 1998; 279:1383-1391.

Year

Law et al

Cutler et al (1991)

Midgley et al

Cutler et al (1997)

Graudal et al

1991 10 9      
1992 15 5      
1993 18 11      
1994 20 9      
1995 26 7      
1996 21 14 11    
1997 32 20 33    
1998 23 6 19 6 10 (part year)

Source: John D. Swales, "Population Advice on Salt Restriction: The Social Issues." Presented to American Society of Hypertension, New York, May 21, 1999.


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